bms 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8326	BMS-2		VEGFR , FLT , c-Met/HGFR
	BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.		VEGFR , FLT , c-Met/HGFR
T2610L	BMS-599626 2HCL(714971-09-2 Free base)	BMS 599626 dihydrochloride,BMS-599626 2HCL(714971-09-2 Free base),AC480 2HCl	HER
	BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferat...		HER
T14688	BMS CCR2 22		CCR
	BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.		CCR
T3146	BMS-202	PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2	Apoptosis , PD-1/PD-L1
	BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction.		Apoptosis , PD-1/PD-L1
T6418	BMS-378806	BMS378806,BMS-806	gp120/CD4 , HIV Protease
	BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.		gp120/CD4 , HIV Protease
T7309	TAS-103 dihydrochloride	TAS-103 (dihydrochloride),BMS-247615 dihydrochloride	Topoisomerase
	TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.		Topoisomerase
T6420	BMS-707035		HIV Protease
	BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.		HIV Protease
T7787	BMS817378		c-Met/HGFR
	BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).		c-Met/HGFR
T4696	BMS202 hydrochloride (1675203-84-5(free base))	PD-1/PD-L1 inhibitor 2 hydrochloride	PD-1/PD-L1
	BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L...		PD-1/PD-L1
T71394	BMS-823778
	BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is a potential therapeutic agent for type 2 diabetes mellitus (T2DM).
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK
T6249	Avagacestat	BMS-708163	Gamma-secretase
	Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.		Gamma-secretase
T2389	Dapagliflozin	BMS-512148	SGLT , HIF
	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.		SGLT , HIF
T26852	BMS-605541	BMS605541,BMS 605541	VEGFR
	BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).		VEGFR
T39789	BMS-986235	BMS-986235,LAR-1219	Others
	BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the preventio...		Others
T6297	Alvespimycin hydrochloride	BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl	Apoptosis , HSP
	Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.		Apoptosis , HSP
T22049	BMS 753		Retinoid Receptor
	BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).		Retinoid Receptor
T6419	BMS-536924	HY-10262,BMS 536924,CS-0117	Apoptosis , FAK , MEK , IGF-1R , Src
	BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.		Apoptosis , FAK , MEK , IGF-1R , Src
T14680	BMS-906024	Osugacestat,AL-101,BM-0018	Gamma-secretase
	BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-...		Gamma-secretase
T4532	Linrodostat	BMS-986205	IDO , Indoleamine 2,3-Dioxygenase (IDO)
	Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.		IDO , Indoleamine 2,3-Dioxygenase (IDO)